Polynucleotides

A next-generation injectable treatment to revitalise, regenerate and restore your skin’s natural glow.

WHAT ARE POLYNUCLEOTIDES? 

Polynucleotides are bio-stimulatory injectables derived from filtered and purified fragments of DNA. Once injected into the skin, they work at a cellular level to repair tissue, reduce inflammation, deeply hydrate and stimulate fibroblasts to regenerate collagen and elastin.

Unlike traditional dermal fillers, polynucleotides don’t add volume. Instead, they improve the quality and function of the skin itself—offering a natural, radiant rejuvenation that enhances your complexion over time.

HOW DO POLYNUCLEOTIDES WORK?

Polynucleotides act as powerful skin healers. By boosting cell turnover and improving skin texture from within, they help reverse signs of ageing, scarring, and dullness.

Key benefits include:

    • Increased collagen and elastin production
    • Improved skin elasticity and firmness
    • Reduced fine lines and wrinkles
    • Enhanced hydration and glow
    • Reduced inflammation and improved healing
    • Visible improvement in acne scarring, pigmentation, and skin texture

Treatment Areas

Polynucleotides can be used across the face and body, with particularly impressive results in delicate areas that are traditionally harder to treat:

    • Periorbital area (under-eye and eyelid rejuvenation)
    • Full face
    • Neck and décolletage
    • Hands
    • Scarring (including acne scars and stretch marks)

WHO ARE POLYNUCLEOTIDES FOR?

This treatment is suitable for patients looking to:

    • Rejuvenate ageing or sun-damaged skin
    • Improve under-eye hollows and crepiness
    • Restore hydration and radiance
    • Address fine lines and wrinkles without filler
    • Support post-procedure healing and skin regeneration

Polynucleotides are safe for all skin types and are an ideal option for those seeking a natural, regenerative alternative to traditional aesthetic treatments.

Treatment Plan & Results

We recommend an initial course of 3 treatments, spaced 2–3 weeks apart, followed by maintenance every 6 months for optimal results. Results are progressive, with visible improvements typically seen after 3–4 weeks, continuing to improve over time.

WHY CHOOSE NSC FOR POLYNUCLEOTIDES?

At Newcastle Skin Clinic, our medically trained team uses only the highest-grade polynucleotide products available on the market ‘Plinest’. Treatments are expertly delivered by aesthetic nurses under the guidance of our Medical Director, Nurse Luisa Scott, ensuring safety, precision, and superior results.

Book a consultation today to discover if polynucleotides are the right solution for your skin.

Polynuclotides start at £225

Luisa’s thoughts

“Polynucleotides are great for restoring a youthful glow without changing facial proportions or expressions like fillers and toxin. This treatment is brilliant for counteracting dark circles under the eyes and strengthening thin delicate skin around the mouth, as well as improving scars and post-blemish scarring. Other benefits are reduction of superficial fine wrinkles, increased collagen production, improved skin texture, hydration and elasticity.”

Luisa Scott
AWARD WINNING AESTHETICS NURSE

Polynucleotides FAQs

Following a medical consultation the Polynucleotide treatment is typically a series of injections spaced a few weeks apart, with the exact number of sessions varying depending on individual needs or goals. Clients will see noticeable improvements after the first few sessions, with optimal results after 3-4 sessions.

Results will be visible from around 6 to 12 weeks after treatment. This treatment works on a cellular level over time, rather than dermal fillers which replace lost volume in the short term.

Maintenance sessions are recommended every 3 – 6 months.

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What our clients think

Caroline Sweet

“Excellent service. Luisa is very knowledgeable and offers good advice. The receptionist is very attentive and friendly. Extremely professional, the clinic is immaculate and a real treat going here! Will definitely be returning and recommending.”

Talia Oatway – Geordie Shore

“Amazing experience every time I go! Wouldn’t go elsewhere!!!”

Lauren Thompson

“Visited Luisa for the first time on Friday – she came highly recommended and I was not disappointed. Had Botox (first time ever) and Luisa took me through each step and I am delighted with the results, and her professionalism with good sound advice for skin care/treatments – can’t wait to go back again”